Morales can be seen in guest and recurring roles on the ABC Family series The Middleman (2008), the USA network series White Collar (2009-2010), the ABC sitcom Trophy Wife (2013-2014), the NBC sitcom Parks and Recreation (2010-2015), and the Netflix series Santa Clarita Diet (2017-2019).
Natalie Morales plays Kate Dalton on the AppleTV+ series The Morning Show.